all you need is a MIDI connection to your computer, and an ASIO audio card. When you run MMV in standalone mode, you will only have two output channels. If your card has more then two outputs, and you want to use them for your virtual synths, you can run several MMV's in a VST host application and route each MMV to a mono or stereo output.
It is also good to have MIDI controllers with lots of knobs to make better use of the virtual synth. Best to have one with parameter feedback, so that the controller displays the actual state, even when the GUI is not visible.
