I used to run my 49 Mk2 through an unpowered USB hub, no issues at all.
In fact at one point I had it connected to my Samsung Thunderbolt Display (which was connected via Thunderbolt to my laptop), again no issue. The display acted like a powered USB hub.
I now use a desktop with around 12 USB ports & 2 T/B so no need for hubs anymore, but my experience shows it can be done.
HTH