I don't know how helpful this will be, but I've encountered two things with the 2S.
Firstly, when sending the Pitch and Gate out to my Minibrute 1 via CV, the last note pressed on the Minibrute 1 keyboard determines the pitch; I can transpose the sequence that way if needed.
Secondly, when setting the pitch of each step of a sequence, it will usually stop at C0...but I can transpose the sequence down an octave or two, and then it will read C-2. You may be able to reach higher note values the same way.