I am also experiencing this problem. MacOS 10.12.2 with an Arturia Microbrute.
Microbrute Connection application is in same folder as MicroBrute_Firmware_Release_V1.0.3.2.mbf
Microbrute is powered on and connected via USB.
When launching Microbrute Connection, I see a dialog box telling me my firmware is outdated. Connection to device appears to be on.
When I accept to update the firmware, I get "Loading error Unable to open the data file". Note at this point that the device no longer appears to be connected.
When the message is dismissed by clicking OK, the connection appears to be re-established:
My Microbrute just arrived yesterday and appears to be running firmware 1.0.0 currently:
I hope someone from Arturia can post a reply with advice. Thanks!