Just got my KeyLab 49 this past Tuesday. Here are some of the minor issues I came across and got past with a little effort. Hopefully some of this might help? I don't know.
Installed it and it worked great after I did the firmware update. Before that the Chords pads werent functioning correctly in Analog lab.
Reason works great, but if I have the midi control center open it wont let me select the keylab, says the midi channel is busy? Closed the midi control center and all was right with the Lab in reason.
The only other issue I had was maybe because of Windows 8.1. It says that if certain propellerhead folders don't show up, to select ALL USERS in C/Users/All users which isn't there, I think it's been changed to "PUBLIC" so I created the folders within this folder and it showed up after that as long as midi control center was closed.
I had a small amount of trouble but it was logical to figure out. This is my first midi controller or synth ( I am mainly a guitar player and I sing) and I thought it was going to be harder than it was. As of now I have no problems that I am aware of (probably because of my ignorance if there are any issues remaining), and I am very happy with this purchase.