To me this is rather strange. I have been giving the inputs i can think of right now. But i assume you have tested it all.
You can try to contact Arturis support. But as said, then Prophet V2 is discontinuet, and i don't think Arturia give support on a trial for V3.
However - i would like to believe, that Arturia is interested in knowing if there are issues with products.
In case Arturia don't read this thread, then perhaps you can point to it, if you contact support.
V3 should run on Sierra. I think Sierra 10.13 have been released, but if that make any difference i don't know. Arturia should know if there have been issues like this with Sierra. But perhaps not with Bitwig, so it's good info if you provide what version of Bitwig you use.
I'm on Windows.
Unless you overload your computer system, then i don't think you should have issues. The specs is more than required. But if you use many things, then it can add up and overload a single CPU core for example.
I hope you find a solution.
Perhaps others know about a solution.