I am more of a unity type of guy and it seems to me that for every release Arturia decided to go different directions in regards to GUI. I personally like GUIs that are practical and also resemble the original hardware synth. But in the end, practicality comes before looks for me. Also, sometimes the original GUI of the hardware synth doesn't translate so well to a softsynth and adjustments need to be made. Maybe it works from a hardware perspective but not software (and some even had original hardware GUI flaws to start with). Anyway, things could be rearranged and still keep the feeling of the original. The Korg Legacy came up with a good solution by having a button switch between the pretty GUI and the practical GUI. It pleases everybody that way. I think Arturia synths are beautiful looking but need some tweaking to make them more practical. Actually, not just Arturia, but many other softsynths could use some of the same tweaking too...
That "hands on" feeling is still a reason why some people like hardware over software. Of course a lot of controllers have dedicated knobs and slides that can send CCs but there's always parameters you can't map and you have go for the mouse. It's almost inevitable, even on softsynths with dedicated controllers like the MS-20 you still need the mouse for switching patches and other settings not available on the hardware controller. There's nothing practical or intuitive about being very precise with the mouse on a small spot on the screen and keeping a steady hand while changing parameters. Too busy GUIs tend to make the parameters too small on the screen and cause that. Also, you may have to squint to see the values for these parameters. Being able to see the synthesizer keys is also not a necessity. It takes real state out of the screen making everything else smaller.
I also think the keyboard should be used more frequently to avoid mouse usage. I've been a software developer for years and this has been the most requested GUI feature since DOS. It's easier and faster to press a keyboard button than a virtual small button with the mouse. Things like changing banks and selecting patches with the arrow keys or perhaps changing views or pages with the pgup and pgdown, etc. could benefit from it.