I have just transfered AFE2.0 license to syncrosoft key, and seems it's been working except for one situation: standalone with Konnekt 24D as output.
with Konnekt 24D configured as an output of AFE2.0, it never responds to MIDI or onscreen mouse click in real time. (as if latency is set to 60 to 120 "secs", not 10 "msecs")
OS: Win XP pro SP2
CPU, Motherboard, etc.: Core 2 Duo E6700/ASUS P5K/3GB RAM
1394 device: motherboard has a VIA chip 1394 interface, another 1394 interface is installed in one of PCI slots.
I have tried other ASIO devices, including creative's soundblaster X-Fi and Edirol's UA-1EX (in advanced mode), and they worked fine. Also, launching AFE2.0 as a VSTi from Cubase 4 runs flawlessly.