Your CPU has a low base speed (frequency), but a high turbo boost speed. Not sure that's too good. I allways go for a high base frequency, but things have developed over the years, so perhaps turbo speed work better now. The problem is, that you reaaly don't know which speed it give you when using turbo, as that's depending on other things.
Many audio processes put the load on one CPU core. So only when using many processes/ perhaps ie even multiple plugins many cores is an advantage.
You can see, if you overload a single core in Windows task manager. It's possible you can't see it in the CPU percentage usage you mention.
Have you set your PC to high performance mode? You should when you work with audio.
Also shut down all background tasks and programs you don't need to run.
Set your soundcard to a samplerate of 44100 or 48000 Hz. And try to start with the buffer at 256 or perhaps 512 samples. Higher buffer settings will give far to high latency when playing, but can be used when mixing to put less load on your CPU.
I will assume your Presonus soundcards control panel has been installed when you installed Presonus ASIO driver. If you have'nt installed and use this driver, then do so.
You find downloads here:
https://www.presonus.com/products/AudioBox-22VSL/downloadsIn Studio One when you are in OPTIONS, and click the tab AUDIO SETUP and the tab AUDIO DEVICE, then you can see your soundcard setup.
In that Windows you also find a button named SONG SETUP. When you click that, you can set the audio setup values for the song. Please consult your Studio One manual to read more about this.
Under the PROCESSING tab instead of the AUDIO DEVICE tab, you have further settings. I'm not a fan of this system - especially when using plugins. I suggest you deselect "Enable low latency monitoring for instruments" and set the Dropout Protection to MINIMUM.
You have a Presonus soundcard, so perhaps you have some functionality for this system, but you have to read and learn about it, and also test it to find out what works best for you.