I have the exact same thing happening in my Cubase 8 OSX 10.10
I don't know if it's because I have the oldest OS required for Polybrute Connect or if it's because I have an older USB cable, but it surely only works intermittently unfortunately. (Works pretty great when it does though)!
Arturia, is there no way in PB Connect to re-sync / reconnect to the Polybrute? Rebooting the Polybrute only seems to reconnect in a way that you can no longer operate it from the DAW. (I must close Cubase, reboot Polybrute and reopen Cubase in an empty project to get it to sync again. THEN open the project I have been working on). Yikes.
I am hopeful that Arturia addresses these issues and makes a rock solid editor through very near future updates.