I am having this issue as well. I'm testing out the Analog Lab 4 demo on my computer. I am using a windows Lenovo Thinkpad T530 with a SSD and 16gb ram. I am running windows 10. I have the audio set to 256 buffer size and a 44100 sample rate. The audio driver is called 'Windows Audio." Whether I run the sound out of the head phone jack of the computer or out of the audio out of a Focusrite 2i4 the audio is very latent. I am using a M-audio keystation 49 to control the notes. When I play the keys of the keyboard, the audio is noticeably delayed. I am hoping to be able to use this set up as a keyboard rig for a live setting, but with this latency its sadly not an option. Is there anything I can do on my end to reduce the latency? 256 is the lowest buffer size Analog lab will permit me to set it to when I am using the 'Windows Driver." There is another driver called "direct sound" but this one will not allow me to route the audio out to an interface. When I set Analog Lab tp "direct sound" and use the headphone jack from the computer, with a buffer size of 64, the sound is completely garbled. Does anyone use this standalone software live? If so, how have you eliminated this latency problem?