I would do the following:
Unpatch everything from the patch bay
Set knobs to 12 o'clock: VCO1 Pitch; Filter Mode; FM; RM; Global Tune
Set knobs to fully clockwise: Cutoff; Master Volume
Set knobs to full counter-clockwise: Everything else
This is basically the init patch.
Set slider to full up: Square OSC Mixer; Both decays
Make sure octave buttons are unlit.
Try again.
Also maybe download and install midi control center and make sure local control didnt get turned off. I've had that happen before with some DAWs.
If all else fails, firmware update and factory reset.