It don't seem like i have that issue using same CS-80 V3 version, VST3 plug-in, Standalone, Windows 10 Home, Studio One 3 Professionel.
I can save detune and and pan settings in stand alone, - in my DAW, - and my DAW also save edited settings that's not saved as preset. Do you have the issue saving in another way?
Otherwise - it perhaps can be a DAW, OS, corrupt preset, or plug-in type related issue.
Sometimes weird things is going on.