Welcome
What software are you running? A screen shot might help because I'm pretty sure it must be something antique to be running on Windows Vista. Certainly the current Analog Lab won't run on anything earlier than Windows 7, which itself is obsolete, so I think we need to establish what software you are using before giving you firm answers.
Without further info I would however hazard a guess you can't save over factory presets.
(Windows Vista? Really? Are you in a time machine calling 2021 from 2007?)
