I am having the same problem. As of 1/8/2011, I am unable to open the stand alone Analog Laboratory. I am currently running mac os x 10.7.2 and the processor is intel i5. I get the splash screen for a few seconds and then it just quits. I recently updated all of the plugins (I have the v collection), and that's when I believe the problem started.
The analog Laboratory opens in Logic Pro. However, upon opening the plugin, I get a very loud squealing sound, and its on full volume! seriously, it is loud enough to hurt someones hearing, I have to switch from the scene screen to sound screen in a hurry to stop that sound, then I am able to use the plugin. Annoying....
I deactivated the ability to open all of the plugins by opening Analog Laboratory (AU) in Logic Pro 9.1.6, and now the stand alone version opens fine. I noticed on the forums, some people are having the same problem. Is there going to be a fix?